Molecular Genomic Approaches to Infectious Diseases in Resource-Limited Settings

Molecular Genomic Approaches to Infectious Diseases in Resource-Limited Settings

Only half a century after the landmark discovery of the double helix structure of DNA, the human genome was sequenced and a new era of biomedical research was ushered in [1]. Parallel advances in comparative genomics, genetics, highthroughput biochemical techniques, and bioinformatics have provided researchers in wealthy nations with a repertoire of tools to analyze the sequence and functions o...

Moving targets: The challenges of studying infectious diseases among pregnant women in resource limited settings

Conducting clinical trials to prevent and treat infectious diseases in pregnancy is essential to saving maternal and newborn lives, though it is fraught with challenges. We have been conducting research in malaria treatment and prevention in children and pregnant women in Blantyre, Malawi for over a decade. Here, we review some of the unique challenges that we have faced in leading research stu...

Resuscitation in resource-limited settings.

Intrapartum-related hypoxia leading to deaths and disabilities continues to be a global challenge, especially in resource-limited settings. Primary prevention during labour is likely to have a significant impact, but secondary prevention with focus on immediate basic stabilization at birth can effectively reduce a large proportion of these adverse outcomes as demonstrated in the resource-rich s...

Innovative Approaches to Clinical Data Management in Resource Limited Settings Using Open-Source Technologies

The primary objective of clinical data management (CDM) is to provide highquality, reliable data for reporting randomized controlled trials (RCTs) in line with good clinical practice (GCP) requirements. For treatment trials of neglected tropical diseases (NTDs) in endemic countries, CDM systems need to be efficient and affordable. Challenges include poor infrastructure, license costs associated...

Viral load testing in resource-limited settings.